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Protection against transplanted and spontaneous lymphoma by inoculation of heat‐altered syngeneic tumor cells in splenectomized mice
Journal article   Peer reviewed

Protection against transplanted and spontaneous lymphoma by inoculation of heat‐altered syngeneic tumor cells in splenectomized mice

Jerome H. Check, Luther W. Brady, Patricia L. Leipold and Elizabeth A. O'Neill
Cancer, v 34(1), pp 197-203
Jul 1974
DOI: https://doi.org/10.1002/1097-0142(197407)34:1<197::AID-CNCR2820340130>3.0.CO;2-R
PMID: 4834179

Abstract

AKR mice with a high incidence of spontaneous lymphoma and leukemia were treated with various combinations of heat‐altered syngeneic tumor cells, BCG, and splenectomy. It was found that the combination of heat‐altered tumor cells and splenectomy markedly inhibited death secondary to both transplanted and spontaneous disease. BCG in combination with altered tumor cells was moderately effective in suppressing transplanted tumors but had no protective effect against spontaneous tumors. Neither splenectomy nor BCG alone offered any protection against spontaneous disease. The results are especially interesting in view of the evidence that there may be immunological tolerance to tumor specific antigens on these leukemia cells. The results may represent the induction of immune materials against an altered tumor antigen which cross‐reacts with unaltered tumor antigens on viable leukemic cells and aids in their destruction. Splenectomy may exert its beneficial effect by reducing circulating enhancing antibodies.

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