Journal article
Protein kinase C activity and contractile responsiveness in senescent blood vessels
European journal of pharmacology. Molecular pharmacology section, v 189(6), pp 405-410
1990
PMID: 2073929
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To examine Ca
2+-signaling receptor function in the aging vasculature, the status of the diacylglycerol/protein kinase C (DAG/PKC) arm of the signal transduction pathway was assessed. Contractile responsiveness to the PKC activator, phorbol 12-myristate 13-acetate (PMA), is substantially reduced in aortae from 24-month-old Fischer 344 rats compared to 6-month-old rats. PKC activity is reduced in all senescent vessels yet studied including aorta, renal artery, iliac artery and vena cava. This may account for the reduced contractile responsiveness. Additionally, PMA-stimulated PKC translocation is substatially reduced in senescent aorta and this may also contribute to reduced contraction.
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Details
- Title
- Protein kinase C activity and contractile responsiveness in senescent blood vessels
- Creators
- Mark D. Johnson - Drexel UniversityHoau-Yan Wang - Woman's Medical College of PennsylvaniaEitan Friedman - Woman's Medical College of Pennsylvania
- Publication Details
- European journal of pharmacology. Molecular pharmacology section, v 189(6), pp 405-410
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1990FJ05500009
- Scopus ID
- 2-s2.0-0025226037
- Other Identifier
- 991019184043904721
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- Web of Science research areas
- Pharmacology & Pharmacy