Journal article
Proteolysis in vitro of low and high density lipoproteins in human plasma by Cerastes cerastes (Egyptian sand viper) venom
Toxicon (Oxford), v 26(9), pp 809-816
1988
PMID: 3144061
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Abstract
Envenomation by snake venoms would be expected to result in proteolysis of plasma proteins as well as of cellular constituents. Incubation of human serum with crude venom from Cerastes cerastes showed that the plasma lipoproteins were a target of this venom. Fractionation of the crude venom by gel filtration revealed that high density lipoprotein (HDL) was susceptible almost exclusively to the highest mol. wt fraction of venom and that proteolysis was due to a metalloprotease. Although HDL was degraded only by this metalloprotease, the low density lipoprotein (LDL) was proteolyzed by both metalloproteases and serine proteases present in several fractions of the venom. Despite extensive degradation, LDL remained intact, as judged by gradient gel electrophoresis. The selectivity of venom fractions may prove useful in the study of lipoprotein structure.
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Details
- Title
- Proteolysis in vitro of low and high density lipoproteins in human plasma by Cerastes cerastes (Egyptian sand viper) venom
- Creators
- M F el-Asmar - Ain Shams Medical School, Cairo, Egypt.J B Swaney - Hahnemann University Hospital
- Publication Details
- Toxicon (Oxford), v 26(9), pp 809-816
- Publisher
- Elsevier
- Grant note
- HL 33827 / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:A1988Q635800006
- Scopus ID
- 2-s2.0-0023742776
- Other Identifier
- 991019350674404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pharmacology & Pharmacy
- Toxicology