Journal article
Proteomic detection of cancer in asbestosis patients using SELDI-TOF discovered serum protein biomarkers
Biomarkers, v 16(2)
01 Mar 2011
PMID: 21231887
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Methods: SELDI-TOF and CART were used to identify serum biomarker profiles in 35 asbestosis patients who subsequently developed cancer and 35 did not develop cancer.
Results: Three polypeptide peaks (5707.01, 6598.10, and 20,780.70 Da) could predict the development of cancer with 87% sensitivity and 70% specificity. The first two peaks were identified as KIF18A and KIF5A, respectively, and are part of the Kinesin Superfamily of proteins.
Conclusions: We identified two Kinesin proteins that can be potentially used as blood biomarkers to identify asbestosis patients at risk of developing lung cancer.
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Details
- Title
- Proteomic detection of cancer in asbestosis patients using SELDI-TOF discovered serum protein biomarkers
- Creators
- Brian C. Tooker - University of Colorado DenverLee S. Newman - Colorado School of Public HealthRussell P. Bowler - National Jewish HealthAntti Karjalainen - Finnish Institute of Occupational HealthPanu Oksa - Finnish Institute of Occupational HealthHarri Vainio - Finnish Institute of Occupational HealthEero Pukkala - Finnish Cancer RegistryPaul W. Brandt-Rauf - University of Illinois Chicago
- Publication Details
- Biomarkers, v 16(2)
- Publisher
- Taylor & Francis
- Number of pages
- 11
- Grant note
- 2 P01 ES011810 / National Institute of Environmental and Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) P01ES011810 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) R01-OH04192; R01-OH07590 / National Institute for Occupational Safety and Health; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA; National Institute for Occupational Safety & Health (NIOSH) R01OH004192 / NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA; National Institute for Occupational Safety & Health (NIOSH)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Web of Science ID
- WOS:000287452000011
- Scopus ID
- 2-s2.0-79951916029
- Other Identifier
- 991019323783904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Toxicology