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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Proteomics advances for precision therapy in ovarian cancer
Expert review of proteomics, v 16(10), pp 841-850
03 Oct 2019
PMID: 31512530
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Introduction: Due to the relatively low mutation rate and high frequency of copy number variation, finding actionable genetic drivers of high-grade serous carcinoma (HGSC) is a challenging task. Furthermore, emerging studies show that genetic alterations are frequently poorly represented at the protein level adding a layer of complexity. With improvements in large-scale proteomic technologies, proteomics studies have the potential to provide robust analysis of the pathways driving high HGSC behavior.
Areas covered: This review summarizes recent large-scale proteomics findings across adequately sized ovarian cancer sample sets. Key words combined with 'ovarian cancer' including 'proteomics', 'proteogenomic', 'reverse-phase protein array', 'mass spectrometry', and 'adaptive response', were used to search PubMed.
Expert opinion: Proteomics analysis of HGSC as well as their adaptive responses to therapy can uncover new therapeutic liabilities, which can reduce the emergence of drug resistance and potentially improve patient outcomes. There is a pressing need to better understand how the genomic and epigenomic heterogeneity intrinsic to ovarian cancer is reflected at the protein level and how this information could be used to improve patient outcomes.
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Details
- Title
- Proteomics advances for precision therapy in ovarian cancer
- Creators
- Marilyne Labrie - Oregon Health & Science UniversityNicholas D Kendsersky - Oregon Health & Science UniversityHongli Ma - Oregon Health & Science UniversityLydia Campbell - Oregon Health & Science UniversityJennifer Eng - Oregon Health & Science UniversityKoei Chin - Oregon Health & Science UniversityGordon B Mills - Oregon Health & Science University
- Publication Details
- Expert review of proteomics, v 16(10), pp 841-850
- Publisher
- Taylor & Francis
- Grant note
- SAC110052 / Susan G. Komen (10.13039/100009634) CA098258; CA217685; CA217842 / National Cancer Institute (10.13039/100000054)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000486515900001
- Scopus ID
- 2-s2.0-85073832234
- Other Identifier
- 991021838689004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemical Research Methods