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Journal article
Pseudomonas aeruginosa dose response and bathing water infection
Epidemiology and infection, v 142(3), pp 449-462
01 Mar 2014
PMID: 24229610
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Pseudomonas aeruginosa is the opportunistic pathogen mostly implicated in folliculitis and acute otitis externa in pools and hot tubs. Nevertheless, infection risks remain poorly quantified. This paper reviews disease aetiologies and bacterial skin colonization science to advance dose-response theory development. Three model forms are identified for predicting disease likelihood from pathogen density. Two are based on Furumoto & Mickey's exponential 'single-hit' model and predict infection likelihood and severity (lesions/m(2)), respectively. 'Third-generation', mechanistic, dose-response algorithm development is additionally scoped. The proposed formulation integrates dispersion, epidermal interaction, and follicle invasion. The review also details uncertainties needing consideration which pertain to water quality, outbreaks, exposure time, infection sites, biofilms, cerumen, environmental factors (e.g. skin saturation, hydrodynamics), and whether P. aeruginosa is endogenous or exogenous. The review's findings are used to propose a conceptual infection model and identify research priorities including pool dose-response modelling, epidermis ecology and infection likelihood-based hygiene management.
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Details
- Title
- Pseudomonas aeruginosa dose response and bathing water infection
- Creators
- D. J. Roser - UNSW SydneyB. Van den Akker - UNSW SydneyS. Boase - Department of Otorhinolaryngology, Head and Neck Surgery, The Queen Elizabeth Hospital, Woodville, SA, AustraliaC. N. Haas - Drexel UniversityN. J. Ashbolt - UNSW SydneyS. A. Rice - UNSW Sydney
- Publication Details
- Epidemiology and infection, v 142(3), pp 449-462
- Publisher
- Cambridge Univ Press
- Number of pages
- 14
- Grant note
- 201300490 / Alberta Innovates
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Civil, Architectural, and Environmental Engineering
- Web of Science ID
- WOS:000332937900001
- Scopus ID
- 2-s2.0-84896448190
- Other Identifier
- 991019168051704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Infectious Diseases
- Public, Environmental & Occupational Health