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Pseudotumoral Sarcoidosis of the Spleen
Journal article   Peer reviewed

Pseudotumoral Sarcoidosis of the Spleen

Sarth Shah, Angela Fast and Alexandra Roudenko
Applied radiology (1976), v 54(5), 250085
01 Dec 2025
DOI: https://doi.org/10.37549/AR-D-25-0085
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Life Sciences & Biomedicine Radiology, Nuclear Medicine & Medical Imaging Science & Technology
Sarcoidosis is a nonneoplastic condition characterized by noncaseating granulomas, primarily in the lungs. This condition is usually asymptomatic; however, extrapulmonary manifestations may exist, including noncaseating granulomas in other organs such as the spleen. On imaging, these lesions may resemble cancer, such as lymphoma, necessitating a biopsy for further histological workup. In patients with a history of malignancy, this workup is absolutely indicated to rule out more ominous conditions compared to the relatively benign condition of sarcoidosis. Once lymphoma and other neoplastic conditions are ruled out, a splenectomy may be performed if the patient is experiencing splenomegaly or pancytopenia to resolve symptomology. In our patient with a cancerous history and confirmed sarcoidosis of the lungs who was experiencing splenomegaly and pancytopenia, radiograph imaging and further histological analysis were absolutely necessary to rule out neoplastic conditions, and a splenectomy was performed to resolve her symptoms.

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Collaboration types
Domestic collaboration
Web of Science research areas
Radiology, Nuclear Medicine & Medical Imaging
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