Journal article
Psoriasis and suicidality: A systematic review and meta-analysis
Journal of the American Academy of Dermatology, v 77(3), pp 425-440
Sep 2017
PMID: 28807109
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Psoriasis is associated with psychiatric comorbidities; however, the relationship between psoriasis and suicidality is not well understood.
To perform a systematic review and meta-analysis that elucidates the relationship between psoriasis and suicidality.
Applying the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we systematically searched the PubMed, EMBASE, PsycINFO, and Cochrane databases. We searched literature published between 1946 and 2017.
We identified 18 studies with a total of 1,767,583 participants, of whom 330,207 had psoriasis. On the basis of random effects modeling, the pooled odds ratio (OR) for suicidal ideation among patients with psoriasis was 2.05 (95% confidence interval [CI], 1.54-2.74). Patients with psoriasis were more likely to exhibit suicidal behaviors (combined attempted and completed suicides) with a pooled OR of 1.26 (95% CI, 1.13-1.40). Subgroup analysis showed that patients with psoriasis were more likely to attempt suicides (OR, 1.32; 95% CI, 1.14-1.54) and complete suicide (OR, 1.20; 95% CI, 1.04-1.39) than those without psoriasis. More severe psoriasis and younger age were associated with greater likelihood of suicidality.
There are few studies examining suicidality in conjunction with psoriasis severity.
Patients with psoriasis have a significantly higher likelihood of suicidal ideation, suicide attempts, and completed suicides. Among patients with psoriasis, those who are younger and whose psoriasis is more severe are at particular risk for suicidality.
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Details
- Title
- Psoriasis and suicidality: A systematic review and meta-analysis
- Creators
- Sanminder Singh - University of California, DavisCatherine Taylor - University of California, DavisHeather Kornmehl - Drexel UniversityApril W. Armstrong - University of Southern California
- Publication Details
- Journal of the American Academy of Dermatology, v 77(3), pp 425-440
- Publisher
- Elsevier
- Number of pages
- 16
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000407494000017
- Scopus ID
- 2-s2.0-85027370629
- Other Identifier
- 991021867508804721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Dermatology