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Psoriasis is associated with lower adjusted in-hospital mortality in acute myocardial infarction: US national inpatient sample study
Journal article   Peer reviewed

Psoriasis is associated with lower adjusted in-hospital mortality in acute myocardial infarction: US national inpatient sample study

Milan Mahesh, Ei Ei Thwe and Nina Cheng
International journal of academic medicine, v 11(4), pp 287-290
01 Oct 2025
DOI: https://doi.org/10.4103/ijam.ijam_52_25

Abstract

General & Internal Medicine Life Sciences & Biomedicine Medicine, General & Internal Science & Technology
Introduction: Psoriasis is a chronic inflammatory disease associated with an increased risk of cardiovascular disease. However, outcomes among patients with psoriasis hospitalized for acute myocardial infarction (AMI) remain inconsistent across studies. We evaluated inpatient characteristics and outcomes of AMI patients with and without psoriasis using a nationally representative U.S. database. Materials and Methods: We performed a retrospective cohort study using the National Inpatient Sample (2016-2019). Adult hospitalizations for AMI were stratified by the presence of psoriasis. Multivariable logistic and linear regression analyses were used to adjust for demographic, clinical, and hospital-level confounders. Results: Among 2.55 million AMI hospitalizations, 15,520 (0.6%) occurred in patients with psoriasis. Compared with patients without psoriasis, those with psoriasis were younger and had significantly higher rates of smoking, alcohol use, diabetes, hypertension, dyslipidemia, prior coronary artery disease, chronic obstructive pulmonary disease, and thyroid disease, but lower rates of congestive heart failure and chronic kidney disease (all P < 0.05). Rates of percutaneous coronary intervention were similar, whereas coronary artery bypass grafting was performed more frequently in patients with psoriasis. Psoriasis was also associated with longer hospital stays and higher hospitalization costs. After multivariable adjustment, psoriasis was independently associated with significantly lower inhospital mortality. Conclusion: Despite the greater burden of traditional cardiovascular risk factors, AMI patients with psoriasis experienced lower inhospital mortality than those without psoriasis. Younger age may partially explain this finding; however, additional studies are needed to clarify the contributions of inflammatory pathways, patient characteristics, and systemic psoriasis therapies to these observed outcomes.The following core competencies are addressed in this article:Patient Care, Medical Knowledge, Practice-Based Learning and Improvement, Systems-Based Practice.

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