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Pulmonary function in hospitalized infants and toddlers with cystic fibrosis
Journal article   Peer reviewed

Pulmonary function in hospitalized infants and toddlers with cystic fibrosis

Russell G Clayton, Carlos E Diaz, Naim S Bashir, Howard B Panitch, Daniel V Schidlow and Julian L Allen
The Journal of pediatrics, v 132(3), pp 405-408
1998
DOI: https://doi.org/10.1016/S0022-3476(98)70010-1
PMID: 9544891
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

G L v̇ maxFRC CF IPFT C L
In older children with cystic fibrosis (CF), well-documented improvements in lung function occur during hospitalization for treatment of pulmonary exacerbations. Objectives: (1) To test the hypothesis that improvement in lung function occurs in infants and toddlers hospitalized because of CF pulmonary exacerbations. (2) To compare changes in lung function measured during forced expiratory flow and tidal breathing. Study design: Seventeen infants and toddlers with CF were evaluated at the beginning and end of hospitalization by the rapid thoracic compression technique to yield maximal flow at forced residual capacity. Tidal mechanics were measured by the esophageal balloon technique to yield lung conductance and compliance. Results: Lung function improved during the course of hospitalization. The greatest change was observed in measurements of maximal flow at functional residual capacity (v̇ maxFRC), increasing from 38.5% ± 6% predicted (mean ± SEM) to 59.8% ± 6% at the end ( p < 0.005). Lung conductance (G L) increased from 60% ± 6% to 78% ± 8% ( p < 0.02); lung compliance (C L) increased from 66% ± 5% to 75% ± 5% ( p < 0.03). The degree of improvement of v̇ maxFRC, G L, and C L was related to baseline measurements; those with poorer pulmonary function at baseline had the greatest degree of improvement during hospitalization. Conclusion: Assessments of airflow obstruction from measurements of v̇ maxFRC and G L do not necessarily demonstrate similar findings in a given infant with CF, perhaps because these two techniques measure different physiologic properties. Changes in v̇ maxFRC may best reflect the predominant pathophysiology of lung disease in infants and toddlers with CF. (J Pediatr 1998;132:405-8) Dr. Allen was supported by HL41132 from the National Institutes of Health.

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Collaboration types
Domestic collaboration
Web of Science research areas
Pediatrics
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