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Journal article
Pulse Pressure Is Associated With Early Brain Atrophy and Cognitive Decline: Modifying Effects of APOE-epsilon 4
Alzheimer disease and associated disorders, v 30(3), pp 210-215
01 Jul 2016
PMID: 27556935
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We investigated whether midlife pulse pressure is associated with brain atrophy and cognitive decline, and whether the association was modified by apolipoprotein-E epsilon 4 (APOE-epsilon 4) and hypertension. Participants (549 stroke-free and dementia-free Framingham Offspring Cohort Study participants, age range=55.0 to 64.9 y) underwent baseline neuropsychological and magnetic resonance imaging (subset, n=454) evaluations with 5- to 7-year follow-up. Regression analyses investigated associations between baseline pulse pressure (systolic-diastolic pressure) and cognition, total cerebral volume and temporal horn ventricular volume (as an index of smaller hippocampal volume) at follow-up, and longitudinal change in these measures. Interactions with APOE-epsilon 4 and hypertension were assessed. Covariates included age, sex, education, assessment interval, and interim stroke. In the total sample, baseline pulse pressure was associated with worse executive ability, lower total cerebral volume, and greater temporal horn ventricular volume 5 to 7 years later, and longitudinal decline in executive ability and increase in temporal horn ventricular volume. Among APOE-epsilon 4 carriers only, baseline pulse pressure was associated with longitudinal decline in visuospatial organization. Findings indicate arterial stiffening, indexed by pulse pressure, may play a role in early cognitive decline and brain atrophy in mid to late life, particularly among APOE-epsilon 4 carriers.
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Details
- Title
- Pulse Pressure Is Associated With Early Brain Atrophy and Cognitive Decline: Modifying Effects of APOE-epsilon 4
- Creators
- Daniel A. Nation - University of Southern CaliforniaSarah R. Preis - Framingham Heart StudyAlexa Beiser - Framingham Heart StudyKatherine J. Bangen - VA San Diego Healthcare SystemLisa Delano-Wood - Vet Affairs San Diego Healthcare Syst, La Jolla, CA USAMelissa Lamar - University of Illinois at ChicagoDavid J. Libon - Drexel UniversitySudha Seshadri - Framingham Heart StudyPhilip A. Wolf - Framingham Heart StudyRhoda Au - Framingham Heart Study
- Publication Details
- Alzheimer disease and associated disorders, v 30(3), pp 210-215
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 6
- Grant note
- R01-NS17950 / National Institute of Neurological Disorders and Stroke; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) N01-HC-25195 / Framingham Heart Study's National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R01NS017950 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01AG016495 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) R01-AG16495; R01-AG08122 / National Institute on Aging; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000383914600003
- Scopus ID
- 2-s2.0-84984614327
- Other Identifier
- 991021901314504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Pathology