Logo image
Back
Pulse contour cardiac output analysis in a piglet model of severe hemorrhagic shock
Journal article   Peer reviewed

Pulse contour cardiac output analysis in a piglet model of severe hemorrhagic shock

Mark D Piehl, James E Manning, Shane L McCurdy, Tim S Rhue, Keith C Kocis, Charles B Cairns and Bruce A Cairns
Critical care medicine, v 36(4), pp 1189-1195
Apr 2008
DOI: https://doi.org/10.1097/CCM.0B013E31816592A3
PMID: 18401255
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Animals Blood Pressure Cardiac Output Disease Models, Animal Linear Models Monitoring, Physiologic - methods Pulse Shock, Hemorrhagic - physiopathology Swine Thermodilution - methods
Pulse contour cardiac output (PCCO) analysis is a technique for continuous cardiac output (CO) monitoring through an arterial catheter after calibration by transpulmonary thermodilution (TPTD). Studies in adults show good correlation with pulmonary artery thermodilution (PATD) CO. Data are limited in children and patients with hemodynamic instability. The objective was to determine whether TPTD CO and PCCO analysis correlate with PATD CO in a piglet model of severe hemorrhagic shock. Mixed venous oxygen saturation (SVO2) was also compared with PATD CO. Prospective animal study. University animal research laboratory. Domesticated piglets, 24-37 kg. Hemorrhagic shock was created by graded hemorrhage in anesthetized piglets. Hemorrhage was initiated to achieve mean arterial pressure plateaus of 60, 50, 40, 30, and 20 mm Hg. CO was measured by PATD and simultaneously with two femoral artery PCCO catheters. At each mean arterial pressure plateau, one PCCO catheter was recalibrated by TPTD; the other catheter was not recalibrated during hemorrhage. TPTD CO, PCCO measurements from each catheter, and SVO2 were compared with PATD CO at each mean arterial pressure level. TPTD CO and recalibrated PCCO showed excellent correlation (r2 = .96 and .97) and small bias (+0.11 and +0.14 L/min), respectively, compared with PATD. Without recalibration, PCCO measurements were not accurate during rapid hemorrhage (r2 = .22). SVO2 decline did not correlate as well with PATD CO (r2 = .69). TPTD CO and recalibrated PCCO analysis correlate well with PATD CO in this severe hemorrhagic shock model. The mean difference is small (<0.15 L/min) and is not clinically significant. With rapid changes in blood pressure or intravascular volume, PCCO is not accurate unless recalibrated by TPTD CO. SVO2 did not correlate well with CO in this model.

Metrics

14 Record Views
24 citations in Web of Science
27 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
Web of Science research areas
Critical Care Medicine
Logo image