Journal article
Pump Position Impacts HeartMate II Left Ventricular Assist Device Thrombosis
ASAIO journal (1992), v 65(3), pp 227-232
Mar 2019
PMID: 29952801
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The PREVENtion of HeartMate II pump Thrombosis through clinical management (PREVENT) study was a multicenter, prospective investigation to evaluate the rate of pump thrombosis (PT) with adoption of a uniform set of surgical and medical practices for left ventricular assist device implantation. We sought to quantify pump position at baseline and retrospectively define a pump position associated with poor clinical outcomes. Chest x-rays at baseline were prospectively obtained per protocol. Pump pocket depth, inflow cannula (IC) angle relative to the pump, and IC angle relative to the vertical were measured. Pumps falling in the tail-ends of the IC angle and pump pocket depth distributions were categorized as having an extreme pump position within the PREVENT study. Patients with extreme pump position had a significantly higher risk of confirmed and suspected PT, hemolysis, and elevated lactate dehydrogenase. In a multivariable analysis of survival free of confirmed PT, extreme pump position was an independent risk factor (hazard ratio = 3.6; 95% confidence interval = 1.5-8.9; p = 0.006) when adjusting for differences in pump speed and anticoagulation level. Our analysis shows that HeartMate II pump position at implant can significantly impact event-free survival and the incidence of adverse events at 6 months.
Metrics
Details
- Title
- Pump Position Impacts HeartMate II Left Ventricular Assist Device Thrombosis
- Creators
- Ahmet Kilic - Johns Hopkins HospitalJohn Ransom - Baptist Health FoundationSimon Maltais - Mayo ClinicBenjamin Sun - Minneapolis Heart Institute FoundationJohn W Entwistle, 3rd - Thomas Jefferson UniversityStephen Bailey - Allegheny General HospitalRanjit John - University of MinnesotaCharles T Klodell - University of Central FloridaIgor Gregoric - Memorial HermannBrett Sheridan - Mayo ClinicJoyce Chuang - Minneapolis Heart Institute FoundationDavid J Farrar - Abbott, Pleasanton, CaliforniaKartik Sundareswaran - Minneapolis Heart Institute FoundationRobert Adamson - Thomas Jefferson University
- Publication Details
- ASAIO journal (1992), v 65(3), pp 227-232
- Publisher
- Lippincott
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Cardiothoracic Surgery
- Web of Science ID
- WOS:000460295000006
- Scopus ID
- 2-s2.0-85064856285
- Other Identifier
- 991021960655604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Transplantation