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Purified Human Mast Cells and Basophils Release Human Elastase and Cathepsin G by an IgE-Mediated Mechanism
Journal article   Peer reviewed

Purified Human Mast Cells and Basophils Release Human Elastase and Cathepsin G by an IgE-Mediated Mechanism

Henry Louis Meier, Lou W Heck, Edward S Schulman and Donald W MacGlashan, Jr
International Archives of Allergy and Immunology, v 77(1-2), pp 179-183
1985
DOI: https://doi.org/10.1159/000233779
PMID: 3924838
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Mast Cells
Human lung mast cells and human peripheral basophils were purified and examined for their content of proteolytic enzymes similar to lung Hageman factor activator (LHFA) previously found to be released from chopped human lung by an IgE-mediated mechanism. It was found that both cell types contained elastase and cathepsin G-like enzymes, and that elastase appeared to be responsible for LHFA activity. The enzymes, as well as histamine, were released in a dose-dependent manner from these cells by anti-IgE antibody and by ionophore A 23187. It appears that stimulation by either anti-IgE or ionophore increases the amount of both enzymes extractable from these cells. The release of these proteases may explain some of the inflammation and observed defects in coagulation which occur as a result of anaphylaxis.

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50 citations in Web of Science
40 citations in Scopus

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This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Allergy
Immunology
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