Journal article
Push or pull: how cytoskeletal crosstalk facilitates nuclear movement through 3D environments
Physical biology, v 19(2), p21003
01 Mar 2022
PMID: 34936999
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
As cells move from two-dimensional surfaces into complex 3D environments, the nucleus becomes a barrier to movement due to its size and rigidity. Therefore, moving the nucleus is a key step in 3D cell migration. In this review, we discuss how coordination between cytoskeletal and nucleoskeletal networks is required to pull the nucleus forward through complex 3D spaces. We summarize recent migration models which utilize unique molecular crosstalk to drive nuclear migration through different 3D environments. In addition, we speculate about the role of proteins that indirectly crosslink cytoskeletal networks and the role of 3D focal adhesions and how these protein complexes may drive 3D nuclear migration.
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Details
- Title
- Push or pull: how cytoskeletal crosstalk facilitates nuclear movement through 3D environments
- Creators
- Pragati C. Marks - Drexel Univ, Dept Biol, Papadakis Integrated Sci Bldg,Room 419 3245 Chest, Philadelphia, PA 41932 USARyan J. Petrie - Drexel University
- Publication Details
- Physical biology, v 19(2), p21003
- Publisher
- IOP Publishing Ltd
- Number of pages
- 9
- Grant note
- 20PRE35170041 / American Heart Association R01GM126054 / National Institute of General Medical Sciences of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000744684000001
- Scopus ID
- 2-s2.0-85123812890
- Other Identifier
- 991019167987504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics