Journal article
Putative Inhibitory Extracellular Matrix Molecules Do Not Prevent Dorsal Root Regeneration into Fetal Spinal Cord Transplants
Neurorehabilitation and neural repair, v 13(2)
Jun 1999
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We examined the distribution of several extracellular matrix molecules (ECM) and their relationship to regenerating axons in embryonic day 14 spinal cord transplants 1 to 12 weeks after transplantation into adult rats. We used immunocytochemical tech niques to label chondroitin sulfate proteoglycans (CSPGs) and tenascin-C in adjacent sections. Synthesis of these molecules by astrocytes is thought to be one mechanism by which astrocytes inhibit regeneration in the central nervous system (CNS); glial fibrillary acidic protein antibody was used to label astrocytes and examine their rela tionship to both the ECM molecules and regenerating calcitonin gene-related pep tide (CORP)-contammg dorsal roots. We also compared the expression and distribu tion of these five markers in transplants with normal spinal cord development.
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Details
- Title
- Putative Inhibitory Extracellular Matrix Molecules Do Not Prevent Dorsal Root Regeneration into Fetal Spinal Cord Transplants
- Creators
- Taku SugawaraB.Timothy HimesMasayoshi KowadaMarion MurrayAlan TesslerWendy P. Battisti
- Publication Details
- Neurorehabilitation and neural repair, v 13(2)
- Publisher
- Sage
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000083333800006
- Scopus ID
- 2-s2.0-0032744214
- Other Identifier
- 991019168752604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Rehabilitation