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Putting Together Pieces of the Lateral Septum: Multifaceted Functions and Its Neural Pathways
Journal article   Open access   Peer reviewed

Putting Together Pieces of the Lateral Septum: Multifaceted Functions and Its Neural Pathways

Candace A Rizzi-Wise and Dong V Wang
eNeuro, v 8(6), pENEURO.0315-21.2021
Nov 2021
DOI: https://doi.org/10.1523/ENEURO.0315-21.2021
PMID: 34764187
url
https://www.eneuro.org/content/eneuro/8/6/ENEURO.0315-21.2021.full.pdfView
Published, Version of Record (VoR) Open
url
https://doi.org/10.1523/ENEURO.0315-21.2021View
Published, Version of Record (VoR) Open

Abstract

Anxiety Fear Hippocampus Neural Pathways Reward
The lateral septum (LS) is implicated as a hub that regulates a variety of affects, such as reward, feeding, anxiety, fear, sociability, and memory. However, it remains unclear how the LS, previously treated as a structure of homogeneity, exhibits such multifaceted functions. Emerging evidence suggests that different functions of the LS are mediated largely by its diverse input and output connections. It has also become clear that the LS is a heterogeneous region, where its dorsal and ventral poles play dissociable and often opposing roles. This functional heterogeneity can often be explained by distinct dorsal and ventral hippocampal inputs along the LS dorsoventral axis, as well as antagonizing connections between LS subregions. Similarly, outputs from LS subregions to respective downstream targets, such as hypothalamic, preoptic, and tegmental areas, also account for this functional heterogeneity. In this review, we provide an updated perspective on LS subregion classification, connectivity, and functions. We also identify key questions that have yet to be addressed in the field.

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