Journal article
Quality of Life Outcomes After Pediatric Otitis Media Surgery: A Systematic Review and Meta-Analysis
The Laryngoscope, v 134(10), pp 4176-4185
Oct 2024
PMID: 38666491
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Systematically review of literature characterizing health-related quality of life (HRQoL) impact of surgery in pediatric otitis media (OM) patients, and meta-analysis of studies using the OM-6 questionnaire.
Pubmed, EMBASE, Cochrane Library, Scopus.
A systematic review of literature of studies evaluating HRQoL outcomes for OM patients managed by surgery. Two investigators independently reviewed abstracts and full-length articles. Risk of bias was assessed using the MINORS criteria and Cochrane Risk of Bias 2 tool.
The search yielded 1272 studies, 50 underwent full-text review and 23 met inclusion criteria. Non-randomized studies were of moderate to good quality, while randomized trials had a high risk of bias. Age ranged from 6 months to 15 years. Race and socioeconomic factors were inconsistently reported. There were 11 HRQoL outcome measure instruments of which four were disease-specific. Eleven studies used OM-6 and nine were included in the meta-analysis. Pooled analysis of five studies showed a mean OM-6 change of 1.79 (95% CI: 1.53-2.06; 95% PI: 0.92-2.67; I
= 68%) 4-6 weeks after surgery; a mean change of 1.87 (95% CI: 1.15-2.58; 98%) after 6 months across two studies; and a mean change of 1.64 (1.02 to 2.27; -6.35 to 9.64; 98%) after 9-13 months across three studies.
There is no consistency in HRQoL instruments used to evaluate pediatric OM surgery outcomes in current literature with few RCTs. Meta-analysis showed a clinically significant large improvement in HRQoL 4-6 weeks after tympanostomy tube placement.
N/A Laryngoscope, 134:4176-4185, 2024.
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Details
- Title
- Quality of Life Outcomes After Pediatric Otitis Media Surgery: A Systematic Review and Meta-Analysis
- Creators
- Doreen Lam - University of PennsylvaniaAlex Fahmy - Drexel UniversityAlisa Timashpolsky - Cleveland ClinicNeel Sangal - University of Pennsylvania Health SystemGanesh Chandrasekaran - University of PennsylvaniaMelanie Cedrone - University of PennsylvaniaKavita Dedhia - Children's Hospital of Philadelphia
- Publication Details
- The Laryngoscope, v 134(10), pp 4176-4185
- Publisher
- Wiley
- Grant note
- K23 DC021217 / NIDCD NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:001208303200001
- Scopus ID
- 2-s2.0-85191340477
- Other Identifier
- 991022202095304721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, Research & Experimental
- Otorhinolaryngology