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Published, Version of Record (VoR)CC BY-NC-ND V4.0, Open
Journal article
Quantifying Color Vision Changes Associated With Cataracts Using Cone Contrast Thresholds
Translational vision science & technology, v 9(12)
Nov 2020
PMID: 33200052
Abstract
To evaluate effects of age and simulated and real cataractous changes on color vision as measured by the high-definition cone contrast test (CCT).
Twenty-four healthy volunteers from two cohort studies performed CCT using best-corrected visual acuity, filters, mydriasis, and pinhole correction. Retrospective cross-sectional study of patients seen in eye clinics evaluated the relationship between age and color vision, and age and lens status in 355 eyes. Last, 25 subjects underwent CCT before and after cataract surgery.
CCT scores were most reliable in the nonmydriatic condition without pinhole correction. Progressively dense brown filters produced small decreases in S-cone sensitivity. Linear regression analysis of phakic subjects showed a decline for all cone classes with age. Rate of decline was greater for S-cones (slope = -1.09; 95% confidence interval [CI], -1.30 to 0.86) than M-cones (slope = -0.80; 95% CI, -1.03 to -0.58) and L-cones (slope = -0.66; 95% CI, -0.88 to -0.44). CCT scores increased for S-cones but reduced for L- and M-cones in pseudophakic subjects compared with phakic patients. CCT scores after cataract surgery increased for S-cones, M-cones, and L-cones by 33.0 (95% CI, 8.6 to 57.4), 24.9 (95% CI, 3.8 to 46.0), and 22.0 (95% CI, -3.2 to 47.3), respectively.
CCT assessment allows for clinically practical quantitation of color and contrast vision improvement after cataract surgery and aging patients who note poor vision despite good visual acuity.
CCT testing, which quantifies hereditary and acquired color deficiency, can also quantify the degree of cataract severity and, combined with other parameters, can provide more precise guidance for cataract extraction to optimize patient care.
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Details
- Title
- Quantifying Color Vision Changes Associated With Cataracts Using Cone Contrast Thresholds
- Creators
- Urmi Mehta - University of California, IrvineAnna Diep - University of California, IrvineKevin Nguyen - Creighton UniversityBryan Le - Drexel UniversityClara Yuh - Western University of Health SciencesCaroline Frambach - University of California, IrvineJohn Doan - Medical College of WisconsinAng Wei - University of California, IrvineAnton M Palma - Translational SciencesMarjan Farid - University of California, IrvineSumit Garg - University of California, IrvineSanjay Kedhar - University of California, IrvineMatthew Wade - University of California, IrvineKailey A Marshall - University of California, IrvineKimberly A Jameson - University of California, IrvineM Cristina Kenney - Gavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, Irvine, California, USAAndrew W Browne - Translational Sciences
- Publication Details
- Translational vision science & technology, v 9(12)
- Publisher
- ARVO
- Grant note
- KL2 TR001416 / NCATS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physical Therapy (and Rehabilitation Sciences)
- Web of Science ID
- WOS:000604294300012
- Scopus ID
- 2-s2.0-85095826318
- Other Identifier
- 991019168072404721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Ophthalmology