Journal article
Quantitative Ocular Surface Changes in Patients Undergoing Immune Checkpoint Inhibitor Therapy
OCULAR IMMUNOLOGY AND INFLAMMATION
18 Sep 2023
PMID: 37722802
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
PurposeTo describe the clinical course and evaluate treatment of ocular surface changes in patients receiving immune checkpoint inhibitor (ICI) therapy.MethodsMultiple markers of ocular surface dryness were evaluated in 16 patients on ICI therapy. The Wilcoxon rank-sum test was used to determine the significant change in the initial and final ocular surface indices.ResultsFifty percent of the eyes demonstrated worsening Schirmer I scores; 29% showed an increase in lissamine green staining. During follow-up, 43% of patients experienced a decline in OSDI scores. Treatments included preservative-free artificial tears (88%), cyclosporine (25%), topical corticosteroids (31%), warm compresses (25%); punctal plugs (13%). Median follow-up time was 3.4 months (range:0-79 ); median ICI treatment duration was 7 months (range:1-40). Four patients died during the observation period.ConclusionA significant proportion of patients experience changes in ocular surface markers while treated with ICIs. Medical intervention can lead to stabilization of ocular surface disease.
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Details
- Title
- Quantitative Ocular Surface Changes in Patients Undergoing Immune Checkpoint Inhibitor Therapy
- Publication Details
- OCULAR IMMUNOLOGY AND INFLAMMATION
- Publisher
- TAYLOR & FRANCIS INC; PHILADELPHIA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:001068376900001
- Scopus ID
- 2-s2.0-85171668578
- Other Identifier
- 991021861281704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Ophthalmology