Journal article
Quantitative Proviral DNA and Antibody Levels in the Natural History of HTLV-I Infection
The Journal of infectious diseases, v 180(5), pp 1487-1493
01 Nov 1999
PMID: 10515807
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The pathogenesis of human T-cell lymphotropic virus type I (HTLV-I) in adult T-cell leukemia/lymphoma (ATL) and HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) is poorly understood. We prospectively followed up and evaluated the virologic correlates of infection in transfusion recipients after seroconversion, in asymptomatic carriers, and in ATL and HAM/TSP patients. Proviral DNA levels (copies/105 lymphocytes) were determined by real-time automated polymerase chain reaction and antibody titers by end-point dilution by use of an HTLV-I enzyme-linked immunoassay. In early infection, proviral load was initially elevated (median, 212 copies/105 lymphocytes at time 1) and later decreased (median, 99 copies at time 2, and 27 copies at time 3). Corresponding antibody titers were low at time 1 (1 : 2154), had significantly increased by time 2 (1 : 12312), and were stable by time 3 (1 : 4694). These viral markers were significantly lower in asymptomatic carriers than in HAM/TSP or ATL patients. Therefore, proviral load and antibody titers may be useful as predictive markers of disease among carriers.
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Details
- Title
- Quantitative Proviral DNA and Antibody Levels in the Natural History of HTLV-I Infection
- Creators
- Angela Manns - National Cancer InstituteWendell J. Miley - Frederick National Laboratory for Cancer ResearchRainford J. Wilks - University of the West Indies SystemOwen St. C. Morgan - University of the West Indies SystemBarrie Hanchard - University of the West Indies SystemGilian Wharfe - University of the West Indies SystemBeverly Cranston - University of the West Indies SystemElizabeth Maloney - National Cancer InstituteSeth L. Welles - University of MinnesotaWilliam A. Blattner - University of Maryland, BaltimoreDavid Waters - Frederick National Laboratory for Cancer Research
- Publication Details
- The Journal of infectious diseases, v 180(5), pp 1487-1493
- Publisher
- The University of Chicago Press
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000083519500010
- Scopus ID
- 2-s2.0-0032730418
- Other Identifier
- 991021012814804721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology