Journal article
Quantitative acoustic characterization of a new surfactant-based ultrasound contrast agent
Ultrasound in medicine & biology, v 23(8), pp 1201-1208
1997
PMID: 9372569
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The acoustic properties of a new ultrasound contrast agent, ST68, have been investigated. ST68 is a sonicated mixture of nonionic surfactants (Span-type and Tween-type) consisting of stabilized microbubbles with a mean diameter of 3.8 μm and a concentration of 7.1 × 10
8 bubbles/mL. A pulsatile flow system was used to acquire data
in vitro. The acoustic properties of ST68, as a function of time, frequency and dose, were calculated. Enhancement changed nonlinearly with contrast agent dose; maximum was 13.1 dB ± 1.0 dB for a dose of 0.30 μL/mL of suspending medium. Attenuation reached approximately 11 dB/cm for dosages above 0.27 μL/mL and for frequencies between 2.5 and 6.0 MHz.
In vivo, IV injections of ST68 were given to 4 rabbits (doses from 0.01 to 0.23 mL/kg). A clear increase in flow signal intensity was observed for 1 to 2 min. An
in vivo dose-response curve was calculated from audio Doppler signals obtained with a 10-MHz cuff transducer placed around the distal aorta. Maximum enhancement was 18.3 dB ± 3.13 dB for a 0.13 mL/kg dose. Moreover, ST68 appears to follow a simple relationship between
in vivo enhancement and dose. In conclusion, ST68 is capable of producing marked vascular enhancement. Its acoustic properties have been characterized
in vitro and
in vivo.
Metrics
Details
- Title
- Quantitative acoustic characterization of a new surfactant-based ultrasound contrast agent
- Creators
- Flemming Forsberg - Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107 USAYunqui Wu - Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107 USAInder R.S Makin - Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107 USAWenhua Wang - Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107 USAMargaret A Wheatley - Department of Chemical Engineering, Drexel University, Philadelphia, PA 19104 USA
- Publication Details
- Ultrasound in medicine & biology, v 23(8), pp 1201-1208
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:A1997YB47700009
- Scopus ID
- 2-s2.0-0030827939
- Other Identifier
- 991014878039604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Acoustics
- Radiology, Nuclear Medicine & Medical Imaging