Files and links (1)
SubmittedOpen Access (License Unspecified), Open
Journal article
Quantitative risk assessment for lung cancer after exposure to bitumen fume
Toxicology and industrial health, v 18(9-10), pp 417-424
Oct 2002
PMID: 15222131
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
An international cohort of asphalt workers was assembled to study cancer risk after bitumen exposure. This article describes the combination of the exposure assessment with the exposure-response for a quantitative risk assessment for lung cancer mortality within the Dutch component of the study. We identified a retrospective cohort of 3,709 workers with at least one season of employment. Semi-quantitative exposure to bitumen fume was estimated by a job-exposure matrix. Exposure-response relations were fitted by Poisson regression, and excess lifetime risks through age 75 were calculated by a life table method. Working lifetime cumulative exposure to bitumen fume was calculated under different scenarios, representing past and future exposures. For workers with exposures accumulated in the past, excess risks for lung cancer varied from 7.8 to 14.3%. Calculations for future exposures resulted in considerably lower excess risks ranging from 0.6 to 2.6%. The calculated excess risks for lung cancer mortality after working lifetime exposure to bitumen fume depend strongly on when exposure was experienced and to some extent on the exposure-response model chosen, while confounding by smoking cannot be ruled out. Nevertheless, the excess lifetime risk for lung cancer in this Dutch cohort of asphalt workers is above benchmark risks as applied by the Dutch Health Council. Current exposure levels have decreased this risk considerably, but further exposure control may be required.
Metrics
Details
- Title
- Quantitative risk assessment for lung cancer after exposure to bitumen fume
- Creators
- Mariëtte Hooiveld - Division Environmental and Occupational Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the NetherlandsIgor Burstyn - Division Environmental and Occupational Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands, Department of Public Health Sciences, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, CanadaHans Kromhout - Division Environmental and Occupational Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the NetherlandsDick Heederik - Division Environmental and Occupational Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands
- Publication Details
- Toxicology and industrial health, v 18(9-10), pp 417-424
- Publisher
- Sage Publications; Thousand Oaks, CA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000222898900001
- Scopus ID
- 2-s2.0-3042585061
- Other Identifier
- 991014878122704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health
- Toxicology