Journal article
Quartz crystal microbalance: Sensing cell-substrate adhesion and beyond
Biosensors & bioelectronics, v 99, pp 593-602
15 Jan 2018
PMID: 28830033
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cell adhesion is an essential aspect of cellular behavior. Finding innovative methods to probe the adhesion of cells in their native state can greatly advance the understanding of control and regulation of cellular behavior and their impact on human health. The quartz crystal microbalance (QCM) is a label-free, biosensing system that has, in the past fifty years, evolved from a simple acoustic based mass sensor to a powerful bioanalytical tool. Its unique capability of monitoring the cell-substrate interaction non-invasively in real time has led to the emergence of its applications in areas that are relevant to fundamental cell biology and medical research. This review is intended to provide readers an overview of the use of the QCM for examination of cell-substrate adhesion. It also describes how this innovative approach can be extended to the study of other aspects of cellular behavior, such as cell morphology, cell mechanics, cell motility, cell signaling, all of which can potentially be applied to medical diagnosis and/or pharmaceutical development. In this review a major emphasis is placed on informing readers about some of the most important practical aspects of the QCM-based cell study including data acquisition and analysis, the substrate surface manipulation, and cell manipulation.
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Details
- Title
- Quartz crystal microbalance: Sensing cell-substrate adhesion and beyond
- Creators
- Jennifer Y Chen - Drexel UniversityLynn S Penn - Drexel UniversityJun Xi - Drexel University
- Publication Details
- Biosensors & bioelectronics, v 99, pp 593-602
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Web of Science ID
- WOS:000413284200078
- Scopus ID
- 2-s2.0-85027522573
- Other Identifier
- 991019168029204721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biophysics
- Biotechnology & Applied Microbiology
- Chemistry, Analytical
- Electrochemistry
- Nanoscience & Nanotechnology