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Journal article
Questions and controversies in the study of time-varying functional connectivity in resting fMRI
Network Neuroscience, v 4(1)
2020
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The brain is a complex, multiscale dynamical system composed of many interacting regions. Knowledge of the spatiotemporal organization of these interactions is critical for establishing a solid understanding of the brain’s functional architecture and the relationship between neural dynamics and cognition in health and disease. The possibility of studying these dynamics through careful analysis of neuroimaging data has catalyzed substantial interest in methods that estimate time-resolved fluctuations in functional connectivity (often referred to as “dynamic” or time-varying functional connectivity; TVFC). At the same time, debates have emerged regarding the application of TVFC analyses to resting fMRI data, and about the statistical validity, physiological origins, and cognitive and behavioral relevance of resting TVFC. These and other unresolved issues complicate interpretation of resting TVFC findings and limit the insights that can be gained from this promising new research area. This article brings together scientists with a variety of perspectives on resting TVFC to review the current literature in light of these issues. We introduce core concepts, define key terms, summarize controversies and open questions, and present a forward-looking perspective on how resting TVFC analyses can be rigorously and productively applied to investigate a wide range of questions in cognitive and systems neuroscience.
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Details
- Title
- Questions and controversies in the study of time-varying functional connectivity in resting fMRI
- Creators
- Daniel J Lurie - University of California, BerkeleyDaniel Kessler - University of MichiganDanielle S Bassett - University of PennsylvaniaRichard F Betzel - University of PennsylvaniaMichael Breakspear - University of Newcastle AustraliaShella Kheilholz - Emory UniversityAaron Kucyi - Stanford UniversityRaphael Liegeois - École Polytechnique Fédérale de LausanneMartin A Lindquist - Johns Hopkins UniversityAanthony Randal McIntosh - University of TorontoRussel A Poldrack - Stanford UniversityJames M Shine - The University of SydneyWillaim Hedley Thompson - Stanford UniversityNatalia Z BielczykLinda Douw - Vrije Universiteit AmsterdamDominik Kraft - Goethe University FrankfurtRobyn L Miller - Mind Research NetworkMuthuraman Muthuraman - University Medical Center of the Johannes Gutenberg University MainzLorenzo Pasquini - University of California, San FranciscoAdeel Razi - Monash UniversityDiego Vidaurre - University of OxfordHua Xie - Stanford UniversityVince D Calhoun - Mind Research Network
- Publication Details
- Network Neuroscience, v 4(1)
- Publisher
- MIT Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000513793200002
- Scopus ID
- 2-s2.0-85138728096
- Other Identifier
- 991021448023304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences