Journal article
Quisqualate and [formula omitted] synergistically excite cerebellar Purkinje cells as a long-term effect
Neuroscience letters, v 107(1), pp 63-69
1989
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Interactions between the excitatory amino acids (EAAs) quisqualate (QUIS) and
N-
methyl-
d-aspartate
(NMDA) were investigated in order to explore mechanisms which may help to explain long-term changes in synaptic efficacy induced by these agents. In 93% of the cerebellar Purkinje (Pnj) cells recorded extracellularly which responded to iontophoretic application of QUIS with increases in discharge of up to 100% above spontaneous levels, NMDA administration sensitized the neuron to further QUIS stimulation by 40–200% over control levels of response. NMDA-enhanced QUIS responses reached maximal levels after termination of NMDA application and persisted for up to 2 h post-NMDA. The NMDA receptor blocker 2-amino-5-phosphonovalerate (APV) prevented the observed effect only when administered before but not after NMDA application, suggesting that a long-lasting post-receptor mechanism may be involved in the observed synergistic interaction of QUIS and NMDA.
Metrics
Details
- Title
- Quisqualate and [formula omitted] synergistically excite cerebellar Purkinje cells as a long-term effect
- Creators
- Sheryl S. Smith - Hahnemann University HospitalSusan S Smith - [Retired Faculty]
- Publication Details
- Neuroscience letters, v 107(1), pp 63-69
- Publisher
- Elsevier Ireland Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1989CE96100011
- Scopus ID
- 2-s2.0-0024336316
- Other Identifier
- 991019184055504721
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- Web of Science research areas
- Neurosciences