Journal article
RESPONSES OF INFRAGRANULAR NEURONS IN THE RAT PRIMARY SOMATOSENSORY CORTEX TO FOREPAW AND HINDPAW TACTILE STIMULI
Neuroscience, v 156(4), pp 1083-1092
28 Oct 2008
PMID: 18775766
Abstract
Infragranular layers constitute the main output of the primary somatosensory cortex and represent an important stage of cortico-cortical and cortico-subcortical integration. We have previously used chronic multiple single-unit recordings to study the spatiotemporal structure of tactile responses of infragranular neurons within the forepaw cortical representation in rats [Tutunculer B, Foffani G, Himes BT, Moxon KA (2006) Structure of the excitatory receptive fields of infragranular forelimb neurons in the rat primary somatosensory cortex responding to touch. Cereb Cortex 16:791810]. Here we extend our understanding of this structure by studying the overlap between the forepaw and hindpaw cortical representations. We recorded 204 responsive neurons in chronic experiments from eight anesthetized rats. Overall, only 23% of neurons responded exclusively to one paw, 52% of neurons responded to two paws, 19% of neurons responded to three paws, and 5% of neurons responded to all four paws. Quantitative measures of response magnitudes and latencies revealed the following main results. (1) The responses of forepaw neurons overall displayed greater magnitudes and shorter latencies than the responses of hindpaw neurons. (2) The responses to ipsilateral stimuli displayed smaller magnitudes, and longer-and more variable-latencies than the responses to contralateral stimuli. (3) The responses of forepaw neurons to hindpaw stimuli displayed smaller magnitudes and longer latencies than the responses to forepaw stimuli, whereas the responses of hindpaw neurons to forepaw stimuli displayed smaller magnitudes but similar latencies compared with the responses to hindpaw stimuli. These results show that the spatiotemporal structure of tactile responses of infragranular neurons extends across all four paws, and provide the basic architecture for studying physiological integration and pathophysiological reorganization of tactile information in the infragranular layers of the rat primary somatosensory cortex. (C) 2008 Published by Elsevier Ltd on behalf of IBRO.
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Details
- Title
- RESPONSES OF INFRAGRANULAR NEURONS IN THE RAT PRIMARY SOMATOSENSORY CORTEX TO FOREPAW AND HINDPAW TACTILE STIMULI
- Creators
- K. A. Moxon - Drexel UniversityL. L. Hale - Drexel UniversityJ. Aguilar - Hospital Nacional de Parapléjicos de ToledoG. Foffani - Drexel University
- Publication Details
- Neuroscience, v 156(4), pp 1083-1092
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- 06056-00 / Consejeria de Sanidad de la Junta de Comunidades de Castilla-La Mancha; Junta de Comunidades de Castilla-La Mancha FISCAM 2P50NS24707 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA PI05 2322 / Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III; Instituto de Salud Carlos III P50NS024707 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000260596000026
- Scopus ID
- 2-s2.0-53949090780
- Other Identifier
- 991019168447504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences