Journal article
REVIEW ■ : Calcium and the Pathogenesis of Traumatic CNS Injury: Cellular and Molecular Mechanisms
The Neuroscientist (Baltimore, Md.), v 3(3)
May 1997
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Under normal conditions in the central nervous system (CNS), the calcium ion (Ca
2+
) is known to mediate a variety of neuronal functions, including synaptic neurotransmitter release, neuronal plasticity, protein phos phorylation, and gene expression. Whereas intracellular calcium concentrations ([Ca
2+
]
i
) are precisely reg ulated through intracellular buffering, binding, and sequestration, alterations in calcium ion homeostasis and influx of Ca
2+
have been implicated in the pathogenesis of neuronal death and degeneration, as well as cerebral vasospasm associated with multiple types of CNS injury. This review revisits the "calcium hypoth esis" of neuronal death associated with traumatic injury to the CNS and examines both the direct and indirect molecular and cellular evidence for calcium-mediated neuropathology, as well as the potential for novel therapeutic strategies targeted at the downstream intracellular effects of calcium signaling and calcium- activated neutral protease (calpain) activation. NEUROSCIENTIST 3:169-175, 1997
Metrics
Details
- Title
- REVIEW ■ : Calcium and the Pathogenesis of Traumatic CNS Injury: Cellular and Molecular Mechanisms
- Creators
- Tracy K. Mcintosh - Head Injury Center Department of Neurosurgery University#R#of Pennsylvania Philadelphia, PennsylvaniaKathryn E. Saatman - Head Injury Center Department of Neurosurgery University#R#of Pennsylvania Philadelphia, PennsylvaniaRamesh Raghupathi - University of Pennsylvania
- Publication Details
- The Neuroscientist (Baltimore, Md.), v 3(3)
- Publisher
- Sage
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:A1997XC96100010
- Scopus ID
- 2-s2.0-3042880163
- Other Identifier
- 991019222909204721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Neurosciences