Journal article
RNA silencing as a cellular defense against HIV-1 infection: progress and issues
The FASEB journal, v 26(10), pp 3937-3945
Oct 2012
PMID: 22751007
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
MicroRNAs (miRNAs) are known to have a role in gene regulation that is closely integrated into the pathways that control virtually all fundamental cell processes of growth, differentiation, metabolism, and death. Whether silencing RNAs and the cellular pathways that generate them are also used in antiviral defense in higher eukaryotes, as they are in plants and lower eukaryotes, has been the subject of much study. Results to date point to a complex interplay between viruses and vertebrate host cells that can vary considerably among different viruses. Here, we review current knowledge regarding interactions between HIV-1 and host cell RNA silencing mechanisms. Important questions in this field remain unresolved, including whether HIV-1 itself encodes small silencing RNAs that might either promote or repress its replication, whether host cell miRNAs can directly target viral transcripts or can alter the course of infection indirectly through effects on cellular genes necessary for viral replication, and whether HIV-1 produces proteins or RNAs that suppress the host-silencing pathway. We summarize evidence and controversies related to the potential role of RNA silencing pathways as a defense against HIV-1 infection.
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Details
- Title
- RNA silencing as a cellular defense against HIV-1 infection: progress and issues
- Creators
- Viraj R Sanghvi - Department of Microbiology and Immunology, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 2245 North 15th St., MS1013A, Philadelphia, PA 19102, USALaura F Steel
- Publication Details
- The FASEB journal, v 26(10), pp 3937-3945
- Publisher
- Wiley; United States
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000309704000002
- Scopus ID
- 2-s2.0-84868097081
- Other Identifier
- 991014877715904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biology
- Cell Biology