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Journal article
RNA viruses and microRNAs: challenging discoveries for the 21st century
Physiological genomics, v 45(22), pp 1035-1048
01 Nov 2013
PMID: 24046280
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
RNA viruses represent the predominant cause of many clinically relevant viral diseases in humans. Among several evolutionary advantages acquired by RNA viruses, the ability to usurp host cellular machinery and evade antiviral immune responses is imperative. During the past decade, RNA interference mechanisms, especially microRNA (miRNA)-mediated regulation of cellular protein expression, have revolutionized our understanding of host-viral interactions. Although it is well established that several DNA viruses express miRNAs that play crucial roles in their pathogenesis, expression of miRNAs by RNA viruses remains controversial. However, modulation of the miRNA machinery by RNA viruses may confer multiple benefits for enhanced viral replication and survival in host cells. In this review, we discuss the current literature on RNA viruses that may encode miRNAs and the varied advantages of engineering RNA viruses to express miRNAs as potential vectors for gene therapy. In addition, we review how different families of RNA viruses can alter miRNA machinery for productive replication, evasion of antiviral immune responses, and prolonged survival. We underscore the need to further explore the complex interactions of RNA viruses with host miRNAs to augment our understanding of host-virus interplay.
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Details
- Title
- RNA viruses and microRNAs: challenging discoveries for the 21st century
- Creators
- Gokul Swaminathan - Drexel UniversityJulio Martin-Garcia - Drexel UniversitySonia Navas-Martin - Drexel University
- Publication Details
- Physiological genomics, v 45(22), pp 1035-1048
- Publisher
- Amer Physiological Soc
- Number of pages
- 14
- Grant note
- R21AI098549 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) NS-061179; AI-088423; DK-089314; NS-065727; AI-098549 / Public Health Service Grants from the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R21DK089314 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R03NS061179 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000327320000001
- Scopus ID
- 2-s2.0-84887588127
- Other Identifier
- 991019168136104721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cell Biology
- Genetics & Heredity
- Physiology