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Journal article
ROX1 and ERG Regulation in Saccharomyces cerevisiae : Implications for Antifungal Susceptibility
Eukaryotic cell, v 1(6), pp 1041-1044
Dec 2002
PMCID: PMC138765
PMID: 12477804
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Abstract
ABSTRACT
Yeasts respond to treatment with azoles and other sterol biosynthesis inhibitors by upregulating the expression of the
ERG
genes responsible for ergosterol production. Previous studies on
Saccharomyces cerevisiae
implicated the
ROX1
repressor in
ERG
regulation. We report that
ROX1
deletion resulted in 2.5- to 16-fold-lower susceptibilities to azoles and terbinafine. In untreated cultures,
ERG11
was maximally expressed in mid-log phase and expression decreased in late log phase, while the inverse was observed for
ROX1
. In azole-treated cultures,
ERG11
upregulation was preceded by a decrease in
ROX1
RNA. These inverse correlations suggest that transcriptional regulation of
ROX1
is an important determinant of
ERG
expression and hence of azole and terbinafine susceptibilities.
Metrics
Details
- Title
- ROX1 and ERG Regulation in Saccharomyces cerevisiae : Implications for Antifungal Susceptibility
- Creators
- Karl W. Henry - Department of Microbiology and ImmunologyJoseph T. Nickels - Drexel UniversityThomas D. Edlind - Department of Microbiology and Immunology
- Publication Details
- Eukaryotic cell, v 1(6), pp 1041-1044
- Publisher
- American Society for Microbiology (ASM)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000179722200020
- Scopus ID
- 2-s2.0-0038671758
- Other Identifier
- 991019168485804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Microbiology
- Mycology