Journal article
Rab35 regulates neurite outgrowth and cell shape
FEBS letters, v 583(7), pp 1096-1101
02 Apr 2009
PMID: 19289122
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recent studies have identified Rab35 in the endocytic pathway and as a regulator of cytokinesis; however its molecular mechanisms are currently unknown. Here, we find that Rab35 colocalizes with actin. laments and with Cdc42, Rac1 and RhoA, and that Rab35 can activate Cdc42 both in vivo and in vitro. We find activated Rab35 stimulates neurite outgrowth in PC12 and N1E-115 cells via a Cdc42-dependent pathway and that siRNA knockdown of Rab35 activity abolishes neurite outgrowth in these cell lines. We conclude that one function of Rab35 is to regulate Rho-family GTPases and that this role has consequences for neurite outgrowth.
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Details
- Title
- Rab35 regulates neurite outgrowth and cell shape
- Creators
- Julien Chevallier - McGill UniversityCharles Koop - McGill UniversityArchana Srivastava - McGill UniversityRyan J. Petrie - McGill UniversityNathalie Lamarche-Vane - McGill UniversityJohn F. Presley - McGill University
- Publication Details
- FEBS letters, v 583(7), pp 1096-1101
- Publisher
- Wiley
- Number of pages
- 6
- Grant note
- Swiss National Science Foundation; Swiss National Science Foundation (SNSF); European Commission FRSQ Chercheur-Boursier; Fonds de la Recherche en Sante du Quebec Canadian Institutes for Health Research; Canadian Institutes of Health Research (CIHR)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000264761800008
- Scopus ID
- 2-s2.0-62849093555
- Other Identifier
- 991020099716804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics
- Cell Biology