Journal article
Race, Ethnicity, and Mortality Following Major Osteoporotic Fracture: Results from the Women's Health Initiative Study
Journal of general internal medicine : JGIM, v 40(11), pp 2583-2592
01 Aug 2025
PMID: 40274741
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Major osteoporotic fracture (MOF) is associated with increased mortality; however, few studies in postmenopausal women have examined racial and ethnic differences in 1-year and 5-year mortality following MOF. Objective: To assess 1-year and 5-year mortality following MOF by race and ethnicity. Design: This prospective cohort study included postmenopausal women enrolled in the Women's Health Initiative (WHI), a population-based, multisite US study. Participants were followed from September 1994 to February 2023. Data were analyzed between August 2023 and November 2023. Participants: Postmenopausal women aged 50 to 79 years old who experienced a MOF (N = 32,675 in 1 year and 29,506 in 5 years following MOF). Main measures: Self-reported race and ethnicity. All-cause mortality was determined by death certificates, reports of surrogates, and the National Death Index Search. Key results: The baseline mean age of participants was 77.0 [SD = 8.5] years with 31,223 [95.6%] White participants in the 1-year mortality analysis, and 76.3 [SD = 8.5] years with 28,212 [95.6%] White participants in the 5-year mortality analysis. In fully adjusted models, compared to White women, Black women had a higher risk of mortality (adjusted odds ratio (aOR) = 1.42, 95% CI [1.06, 1.90], while Asian women had a lower risk of mortality (aOR = 0.48 95% CI [0.27, 0.88]), within 1 year following MOF. Compared to White women, the mortality risk within 5 years after MOF was significantly higher among American Indian/Alaska Native (aOR = 3.30, 95% CI [1.65, 6.60]) and lower among Asian (aOR = 0.58, 95% CI [0.42,0.80]) women. While there were no mortality differences by ethnicity 1 year following MOF, Hispanic/Latina women were less likely to die 5 years following MOF (aOR = 0.74, [95% CI 0.57-0.96]) compared to Non-Hispanic/Latina women. Conclusions: In this large prospective study, mortality following MOF differed by race. Future research is needed to delineate the mechanism behind these associations.
Metrics
1 Record Views
Details
- Title
- Race, Ethnicity, and Mortality Following Major Osteoporotic Fracture: Results from the Women's Health Initiative Study
- Creators
- Michaela Juels (Corresponding Author) - University of California, Los AngelesJoseph C. Larson - Fred Hutch Cancer CenterKristine E. Ensrud - University of MinnesotaMarcia L. Stefanick - Stanford Health CareAladdin H. Shadyab - University of California San DiegoLorena Garcia - University of California, DavisRami Nassir - Umm al-Qura UniversityPeter F. Schnatz - Reading HospitalRebecca Nelson - City of HopeCarolyn J. Crandall - University of California, Los Angeles
- Publication Details
- Journal of general internal medicine : JGIM, v 40(11), pp 2583-2592
- Publisher
- Springer Nature
- Number of pages
- 10
- Grant note
- 75 N92021D00001; 75 N92021D00002; 75 N92021D00003; 75 N92021D00004; 75 N92021D00005 / National Heart, Lung, and Blood Institute, National Institutes of Health, US Department of Health and Human Services; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Obstetrics and Gynecology
- Web of Science ID
- WOS:001474081600001
- Scopus ID
- 2-s2.0-105003502806
- Other Identifier
- 991022197302304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
Source: SDGs in the Output
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Health Care Sciences & Services