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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Race/ethnicity and telomere length in the Multi-Ethnic Study of Atherosclerosis
Aging cell, v 8(3), pp 251-257
17 Mar 2009
PMID: 19302371
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Telomere length has emerged as a marker of exposure to oxidative stress and aging. Race/ethnic differences in telomere length have been infrequently investigated. Leucocyte telomere length (LTL) was assessed 981 white, black and Hispanic men and women aged 45-84 years participating in the Multi-Ethnic Study of Atherosclerosis. Direct measurement and questionnaire were used to assess covariates. Linear regression was used to estimate associations of LTL with race/ethnicity and age after adjustment for sex, income, education, smoking, physical activity, diet, and body mass index. On average blacks and Hispanics had shorter telomeres than whites (adjusted mean differences (standard error) in T/S ratio compared to whites: -0.041 (0.018) for blacks and -0.044 (0.018) for Hispanics). Blacks and Hispanics showed greater differences in telomere length associated with age than whites (adjusted mean differences in T/S ratio per one year increase in age -0.0018, -0.0047, and -0.0055 in whites, blacks, and Hispanics respectively). Differences in age associations were more pronounced and only statistically significant in women. Race/ethnic differences in LTL may reflect the cumulative burden of differential exposure to oxidative stress (and its predictors) over the lifecourse.
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Details
- Title
- Race/ethnicity and telomere length in the Multi-Ethnic Study of Atherosclerosis
- Creators
- Ana V. Diez Roux (Corresponding Author) - University of MichiganNalini Ranjit - University of MichiganNancy Swords Jenny - University of VermontSteven Shea - Columbia UniversityMary Cushman - University of VermontAnnette Fitzpatrick - University of WashingtonTeresa Seeman - University of California, Los Angeles
- Publication Details
- Aging cell, v 8(3), pp 251-257
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000266417700004
- Scopus ID
- 2-s2.0-66149171509
- Other Identifier
- 991020100192104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology
- Geriatrics & Gerontology