Journal article
Racial and Regional Differences in Venous Thromboembolism in the United States in 3 Cohorts
Circulation (New York, N.Y.), v 129(14), pp 1502-1509
08 Apr 2014
PMID: 24508826
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background Blacks are thought to have a higher risk of venous thromboembolism (VTE) than whites. However, prior studies are limited to administrative databases that lack specific information on VTE risk factors or have limited geographic scope.
Methods and Results We ascertained VTE from 3 prospective studies: the Atherosclerosis Risk in Communities Study (ARIC), the Cardiovascular Health Study (CHS), and the Reasons for Geographic and Racial Differences in Stroke study (REGARDS). We tested the association of race with VTE using Cox proportional hazard models adjusted for VTE risk factors. Over 438 090 person-years, 916 incident VTE events (302 in blacks) occurred in 51 149 individuals (17 318 blacks) who were followed up. In risk factor-adjusted models, blacks had a higher rate of VTE than whites in the CHS (hazard ratio, 1.81; 95% confidence interval, 1.20-2.73) but not ARIC (hazard ratio, 1.21; 95% confidence interval, 0.96-1.54). In REGARDS, there was a significant region-by-race interaction (P=0.01): Blacks in the Southeast had a significantly higher rate of VTE than blacks in the rest of the United States (hazard ratio, 1.63; 95% confidence interval, 1.08-2.48) that was not seen in whites (hazard ratio, 0.83; 95% confidence interval, 0.61-1.14).
Conclusions The association of race with VTE differed in each cohort, which may reflect the different time periods of the studies or different regional rates of VTE. Further studies of environmental and genetic risk factors for VTE are needed to determine which underlie racial and perhaps regional differences in VTE.
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Details
- Title
- Racial and Regional Differences in Venous Thromboembolism in the United States in 3 Cohorts
- Creators
- Neil A. Zakai - University of VermontLeslie A. McClure - University of Alabama at BirminghamSuzanne E. Judd - University of MinnesotaMonika M. Safford - University of Alabama at BirminghamAaron R. Folsom - University of MinnesotaPamela L. Lutsey - University of MinnesotaMary Cushman - University of Vermont
- Publication Details
- Circulation (New York, N.Y.), v 129(14), pp 1502-1509
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 8
- Grant note
- HHSN268201100005C; HHSN268201100006C; HHSN2682011 00007C; HHSN268201100008C; HHSN268201100009C; HHSN 268201100010C; HHSN268201100011C; HHSN2682011 00012C; HHSN268201200036C; HHSN268200800007; N01 HC55222; N01HC85079; N01HC85080; N01HC85081 / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) AG023629 / National Institute on Aging; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) R56AG023629 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) P30DK079626 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) NS 041588 / National Institute of Neurological Disorders and Stroke; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) RC1HL099460 / American Recovery and Reinvestment Act grant from the National Heart, Lung, and Blood Institute R01HL080295 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) P20MD006899 / National Institute on Minority Health and Health Disparities; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Minority Health & Health Disparities (NIMHD) National Institute of Neurological Disorders and Stroke; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) U01NS041588 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000335369900010
- Scopus ID
- 2-s2.0-84898052014
- Other Identifier
- 991019231634104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Peripheral Vascular Disease