Journal article
Racial differences in nonalcoholic fatty liver disease in the US population
Obesity (Silver Spring, Md.), v 22(1)
Jan 2014
PMID: 23512725
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective To characterize the prevalence of nonalcoholic fatty liver disease (NAFLD) by race in a nationally representative sample of the U.S. population and to investigate potential explanatory factors for racial disparities. Design and Methods Cross-sectional study of 4,037 non-Hispanic white, 2,746 non-Hispanic black, and 2,892 Mexican-American adults in the Third National Health and Nutrition Examination Survey. NAFLD was defined using ultrasound and with elevated aminotransferases. Results Age-adjusted prevalence of NAFLD was highest in Mexican-Americans (21.2%), followed by non-Hispanic whites (12.5%), and was lowest in non-Hispanic blacks (11.6%). Even after adjustment for demographic, lifestyle, adiposity, and metabolic factors, compared to non-Hispanic whites, Mexican-Americans were more likely to have NAFLD (OR: 1.67, 95% CI: 1.26, 2.22). Non-Hispanic blacks were significantly less likely to have NAFLD with elevated aminotransferases (OR: 0.51, 95% CI: 0.27, 0.97). Racial differences were attenuated among those with normal BMI and among never drinkers. Conclusion In this representative sample of the U.S. population, we found significant racial differences in the prevalence of ultrasound-defined NAFLD (with and without elevated liver enzymes). The racial differences were not fully explained by lifestyle, adiposity, and metabolic factors. More works is needed to identify potential contributors.
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Details
- Title
- Racial differences in nonalcoholic fatty liver disease in the US population
- Creators
- Andrea L. C. Schneider - Johns Hopkins UniversityMariana Lazo - Johns Hopkins UniversityElizabeth Selvin - Johns Hopkins UniversityJeanne M. Clark - Johns Hopkins University
- Publication Details
- Obesity (Silver Spring, Md.), v 22(1)
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- P30DK089502 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) UL1TR001079 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) T32 DK062707; K01 DK076595; R01 DK089174; R01 DK083393 / NIH/NIDDK; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) American Diabetes Association
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000329613600042
- Scopus ID
- 2-s2.0-84892370481
- Other Identifier
- 991020550347604721
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- Web of Science research areas
- Endocrinology & Metabolism
- Nutrition & Dietetics