Journal article
Radioimmunotherapy as a novel treatment regimen: 125I-labeled monoclonal antibody 425 in the treatment of high-grade brain gliomas
International journal of radiation oncology, biology, physics, v 58(3), pp 972-975
Mar 2004
PMID: 14967458
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A Phase I/II clinical trial was undertaken between January 29, 1987 and January 25, 1997 to assess the efficacy of 125I-labeled monoclonal antibody 425 (125I-MAb 425) in controlling high-grade brain gliomas. A total of 180 patients diagnosed with glioblastoma multiforme (GBM) and astrocytoma with anaplastic foci (AAF) were administered 125I-MAb 425 as an adjuvant treatment. All underwent initial surgery followed by postoperative external beam radiation therapy and a cumulative dose of 140 mCi of 125I-MAb 425. Biodistribution of radioactivity after antibody administration showed increased uptake in brain tumor cells due to enhanced expression of epidermal growth factor receptors. A longer half-life of 125I-MAb 425 in brain tumor cells compared to blood was observed. All patients were followed up for at least 5 years. Overall actuarial survival range for GBM and AAF patients showed 4-150 and 4-270 months, respectively. GBM and AAF patients under age 40 years with a Karnofsky performance status >70 had an actuarial median survival of 22.5 and 65 months, respectively. This adjuvant therapy demonstrates a significant increase in median survival and should be considered in the management of high-grade brain gliomas.
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Details
- Title
- Radioimmunotherapy as a novel treatment regimen: 125I-labeled monoclonal antibody 425 in the treatment of high-grade brain gliomas
- Creators
- Tony S. Quang - Department of Radiation Oncology, Hahnemann University Hospital of Drexel University College of Medicine, Philadelphia, PA, USALuther W. Brady - Drexel University
- Publication Details
- International journal of radiation oncology, biology, physics, v 58(3), pp 972-975
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000188934600042
- Scopus ID
- 2-s2.0-1242293091
- Other Identifier
- 991019169533804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging