Journal article
Radiosensitization of malignant melanoma—I: The effect of 7-hydroxy-chlorpromazine on the in vivo radiation response of Fortner's melanoma
International journal of radiation oncology, biology, physics, v 4(9), pp 821-824
1978
PMID: 711551
Abstract
A number of investigators have reported the radiosensitizing effects of chlorpromazine (CPZ) in the treatment of malignant melanoma. In the present study, we explored radiosensitization of Fortner's melanoma in the hamster, by the use of the 7-hydroxy metabolite (7-OHCPZ) of CPZ. In conjunction with orthovoltage photon radiation (XRT), 7-OHCPZ was found to repress mean tumor growth by as much as 54%, 56%, 38%, and 53%, respectively, compared to XRT alone, 7-OHCPZ alone, CPZ + XRT, and no treatment. These results may be related to the greater affinity for melanin of 7-OHCPZ than CPZ. Possible therapeutic mechanisms are discussed.
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Details
- Title
- Radiosensitization of malignant melanoma—I: The effect of 7-hydroxy-chlorpromazine on the in vivo radiation response of Fortner's melanoma
- Creators
- Jeffrey I. Damsker - Hahnemann University HospitalRoger Macklis - Hahnemann University HospitalLuther W. Brady - Hahnemann University HospitalEdward A. Nodiff - Franklin InstituteHahnemann Medical Coll. and Hospital, Philadelphia
- Publication Details
- International journal of radiation oncology, biology, physics, v 4(9), pp 821-824
- Publisher
- Elsevier; OXFORD
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:A1978FS82100007
- Scopus ID
- 2-s2.0-0018186259
- Other Identifier
- 991021901006604721