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Radiotherapy in the treatment of gastrointestinal stromal tumor
Journal article   Open access   Peer reviewed

Radiotherapy in the treatment of gastrointestinal stromal tumor

Christin A. Knowlton, Luther W. Brady and Rebecca C. Heintzelman
Rare tumors, v 3(4), pp 111-113
24 Oct 2011
DOI: https://doi.org/10.4081/rt.2011.e35
PMID: 22355490
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.4081/rt.2011.e35View
Published, Version of Record (VoR)CC BY-NC V4.0,  Open

Abstract

Case Report gastrointestinal stromal tumor GIST radiation therapy radiotherapy
Gastrointestinal stromal tumors (GISTs) are uncommon mesenchymal tumors of the gastrointestinal tract. Up to one-third of GISTs are malignant with a high rate of metastasis. Surgical resection is the mainstay of care for patients with resectable disease. Imatinib mesylate, a selective tyrosine kinase inhibitor, is the current standard of care for GISTs that cannot be completely resected or in cases of metastatic GIST. Although often overlooked, radiation therapy is a viable option for select patients with GIST. We report the case of a patient with unresectable GIST who was treated with local radiotherapy and achieved long-term response. We also present a review of the literature regarding the use of radiotherapy in the treatment of GIST. GIST has been shown to be a radiosensitive tumor. Radiotherapy can offer long-term local control and should be considered in the adjuvant or palliative setting. The role of radiotherapy delivered concurrently with imatinib in the treatment of GIST may warrant further investigation.

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20 citations in Web of Science
22 citations in Scopus

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Web of Science research areas
Oncology
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