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Published, Version of Record (VoR)CC BY-NC V4.0, Open
Journal article
Radiotherapy in the treatment of gastrointestinal stromal tumor
Rare tumors, v 3(4), pp 111-113
24 Oct 2011
PMCID: PMC3282440
PMID: 22355490
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Gastrointestinal stromal tumors (GISTs) are uncommon mesenchymal tumors of the gastrointestinal tract. Up to one-third of GISTs are malignant with a high rate of metastasis. Surgical resection is the mainstay of care for patients with resectable disease. Imatinib mesylate, a selective tyrosine kinase inhibitor, is the current standard of care for GISTs that cannot be completely resected or in cases of metastatic GIST. Although often overlooked, radiation therapy is a viable option for select patients with GIST. We report the case of a patient with unresectable GIST who was treated with local radiotherapy and achieved long-term response. We also present a review of the literature regarding the use of radiotherapy in the treatment of GIST. GIST has been shown to be a radiosensitive tumor. Radiotherapy can offer long-term local control and should be considered in the adjuvant or palliative setting. The role of radiotherapy delivered concurrently with imatinib in the treatment of GIST may warrant further investigation.
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Details
- Title
- Radiotherapy in the treatment of gastrointestinal stromal tumor
- Creators
- Christin A. Knowlton - Department of Radiation Oncology;Luther W. Brady - Drexel UniversityRebecca C. Heintzelman - Drexel University
- Publication Details
- Rare tumors, v 3(4), pp 111-113
- Publisher
- PAGEPress Publications
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine); Pathology (and Laboratory Medicine)
- Web of Science ID
- WOS:000219601300001
- Scopus ID
- 2-s2.0-80355132451
- Other Identifier
- 991019168874104721
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- Web of Science research areas
- Oncology