Journal article
Raised histamine concentrations in chronic cholestatic liver disease
Gut, v 31(1), pp 96-99
Jan 1990
PMID: 2108078
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Pruritus is a frequent symptom in chronic cholestatic liver disease. To date, no single causative mechanism has been identified. We examined venous plasma concentrations of the known pruritogen, histamine, using a highly sensitive radioenzymatic assay in 42 patients with chronic cholestatic liver disease, and in normal controls. The mean plasma histamine level was significantly greater in chronic cholestatic liver disease patients (275 (117) pg/ml; X (SD) than in controls (140 (72) pg/ml, n = 20) (p less than 0.0001). No significant differences were found between histamine concentrations in the two chronic cholestatic liver disease subgroups: primary biliary cirrhosis and sclerosing cholangitis. Histamine concentrations were significantly greater (p less than 0.01) in the pruritic (319 (132) pg/ml) as compared with the non-pruritic (227 (75) pg/ml) chronic cholestatic liver disease patients. The histaminase activity was equivalent in patients and controls. The finding of raised histamine concentrations in chronic cholestatic liver disease suggests in vivo mast cell activation and a potential role for its mediators in the pruritus characteristic of these disorders.
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Details
- Title
- Raised histamine concentrations in chronic cholestatic liver disease
- Creators
- S D Gittlen - Thomas Jefferson UniversityE S Schulman - Thomas Jefferson UniversityW C Maddrey - Thomas Jefferson University
- Publication Details
- Gut, v 31(1), pp 96-99
- Publisher
- BMJ Publishing Group Ltd and British Society of Gastroenterology
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pulmonary, Critical Care, and Sleep (Medicine)
- Web of Science ID
- WOS:A1990CL16700018
- Scopus ID
- 2-s2.0-0025020351
- Other Identifier
- 991021934874404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Gastroenterology & Hepatology