Journal article
Raman Spectroscopy Detects Cardiac Allograft Rejection with Molecular Specificity
Clinical and translational science, v 2(3)
01 Jun 2009
PMID: 20443894
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Spatially resolved Raman spectroscopy is shown here to be capable of molecular‐specific detection without exogenous labeling. This molecular specificity is achieved by detecting the strong and characteristic Raman spectral signature of an indole derivative, serotonin, whose selective existence in rejected heart transplants serves as the biomarker. The study also corroborates the increasingly recognized role of serotonin receptors in various immune responses, including cardiac allograft rejection. Combining both medical and physical sciences, this work demonstrates the potential use of Raman spectroscopy in replacing the invasive endomyocardial biopsy as the standard for post‐transplantation rejection surveillance and presents a new paradigm in advancing clinical care through interdisciplinary studies.
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Details
- Title
- Raman Spectroscopy Detects Cardiac Allograft Rejection with Molecular Specificity
- Creators
- Yoon Gi Chung - School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, USA Division of Cardiology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA Department of Pathology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USAQiang Tu - School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, USA Division of Cardiology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA Department of Pathology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USADianjun Cao - School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, USA Division of Cardiology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA Department of Pathology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USAShuko Harada - Drexel UniversityHoward J Eisen - Drexel UniversityChang Chang - Drexel University
- Publication Details
- Clinical and translational science, v 2(3)
- Publisher
- Blackwell Publishing Inc
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000272843300013
- Scopus ID
- 2-s2.0-77953417288
- Other Identifier
- 991019330794404721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Medicine, Research & Experimental