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Journal article
Random versus directionally persistent cell migration
Nature reviews. Molecular cell biology, v 10(8), pp 538-549
01 Aug 2009
PMID: 19603038
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Directional migration is an important component of cell motility. Although the basic mechanisms of random cell movement are well characterized, no single model explains the complex regulation of directional migration. Multiple factors operate at each step of cell migration to stabilize lamellipodia and maintain directional migration. Factors such as the topography of the extracellular matrix, the cellular polarity machinery, receptor signalling, integrin trafficking, integrin co-receptors and actomyosin contraction converge on regulation of the Rho family of GTPases and the control of lamellipodial protrusions to promote directional migration.
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Details
- Title
- Random versus directionally persistent cell migration
- Creators
- Ryan J. Petrie - National Institute of Dental and Craniofacial ResearchAndrew D. Doyle - National Institute of Dental and Craniofacial ResearchKenneth M. Yamada - National Institute of Dental and Craniofacial Research
- Publication Details
- Nature reviews. Molecular cell biology, v 10(8), pp 538-549
- Publisher
- Springer Nature
- Number of pages
- 12
- Grant note
- ZIADE000718 / NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR) Z01 DE000524-17 / Intramural NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000268238200015
- Scopus ID
- 2-s2.0-68049083547
- Other Identifier
- 991020100070904721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cell Biology