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Randomized comparison of the effects of the vitamin D-3 adequate intake versus 100 mcg (4000 IU) per day on biochemical responses and the wellbeing of patients
Journal article   Open access   Peer reviewed

Randomized comparison of the effects of the vitamin D-3 adequate intake versus 100 mcg (4000 IU) per day on biochemical responses and the wellbeing of patients

Reinhold Vieth, Samantha Kimball, Amanda Hu and Paul G. Walfish
Nutrition journal, v 3
01 Jan 2004
DOI: https://doi.org/10.1186/1475-2891-3-8
PMID: 15260882
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1186/1475-2891-3-8View
Published, Version of Record (VoR)CC BY V4.0,  Open

Abstract

Life Sciences & Biomedicine Nutrition & Dietetics Science & Technology
Background: For adults, vitamin D intake of 100 mcg (4000 IU)/day is physiologic and safe. The adequate intake (AI) for older adults is 15 mcg (600 IU)/day, but there has been no report focusing on use of this dose. Methods: We compared effects of these doses on biochemical responses and sense of wellbeing in a blinded, randomized trial. In Study 1, 64 outpatients (recruited if summer 2001 25(OH) D < 61 nmol/L) were given 15 or 100 mcg/day vitamin D in December 2001. Biochemical responses were followed at subsequent visits that were part of clinical care; 37 patients completed a wellbeing questionnaire in December 2001 and February 2002. Subjects for Study 2 were recruited if their 25(OH) D was < 51 nmol/L in summer 2001. 66 outpatients were given vitamin D; 51 completed a wellbeing questionnaire in both December 2002 and February 2003. Results: In Study 1, basal summer 25-hydroxyvitamin D [25(OH) D] averaged 48 +/- 9 (SD) nmol/L. Supplementation for more than 6 months produced mean 25(OH) D levels of 79 +/- 30 nmol/L for the 15 mcg/day group, and 112 +/- 41 nmol/L for the 100 mcg/day group. Both doses lowered plasma parathyroid hormone with no effect on plasma calcium. Between December and February, wellbeing score improved more for the 100-mcg/day group than for the lower-dosed group (1-tail Mann-Whitney p = 0.036). In Study 2, 25(OH) D averaged 39 +/- 9 nmol/L, and winter wellbeing scores improved with both doses of vitamin D (two-tail p < 0.001). Conclusion: The highest AI for vitamin D brought summertime 25(OH) D to > 40 nmol/L, lowered PTH, and its use was associated with improved wellbeing. The 100 mcg/day dose produced greater responses. Since it was ethically necessary to provide a meaningful dose of vitamin D to these insufficient patients, we cannot rule out a placebo wellbeing response, particularly for those on the lower dose. This work confirms the safety and efficacy of both 15 and 100 mcg/day vitamin D3 in patients who needed additional vitamin D.

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175 citations in Web of Science
200 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Web of Science research areas
Nutrition & Dietetics
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