Journal article
Rapid Adsorption of Proinflammatory Cytokines by Graphene Nanoplatelets and Their Composites for Extracorporeal Detoxification
Journal of nanomaterials, v 2018, pp 1-8
21 Feb 2018
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sepsis is a complex clinical syndrome that features excessive release of cytokines and other inflammatory mediators that could lead to organ dysfunction. Despite different treatment and management options, sepsis associated high morbidity and mortality rates remain. This has prompted intensive research into alternative therapeutic approaches such as targeted removal of sepsis related molecules using extracorporeal hemoperfusion. In this study, we explore the use of graphene nanoplatelets (GNP) as low-cost alternative hemosorbents for rapid removal of a broad spectrum of proinflammatory cytokine markers. Firstly, the physical characteristics, cytotoxicity, and cytokine marker adsorption profile of GNP were assessed. The results not only confirmed the surface characteristics of GNP and their ability to rapidly remove cytokine markers, but also indicated a low cytotoxicity towards the hepatic cell line HepG2. GNP were then incorporated into a freestanding flexible GNP-poly(tetrafluoroethylene) film with preserved surface characteristics and cytokine adsorption profile for potential use in hemoperfusion applications.
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Details
- Title
- Rapid Adsorption of Proinflammatory Cytokines by Graphene Nanoplatelets and Their Composites for Extracorporeal Detoxification
- Creators
- Yishan Zheng - School of Pharmacy and Biomolecular Sciences University of Brighton Brighton BN2 4GJ UK brighton.ac.ukNicholas Pescatore - Department of Materials Science & Engineering and A. J. Drexel Nanomaterials Institute Drexel University Philadelphia PA 19104 USA drexel.eduYury Gogotsi - Department of Materials Science & Engineering and A. J. Drexel Nanomaterials Institute Drexel University Philadelphia PA 19104 USA drexel.eduBoris Dyatkin - Department of Materials Science & Engineering and A. J. Drexel Nanomaterials Institute Drexel University Philadelphia PA 19104 USA drexel.eduGanesh Ingavle - School of Pharmacy and Biomolecular Sciences University of Brighton Brighton BN2 4GJ UK brighton.ac.ukVadym Mochalin - Department of Chemistry and Department of Materials Science & Engineering Missouri University of Science & Technology Rolla MO 65409 USA mst.eduTochukwu Ozulumba - School of Pharmacy and Biomolecular Sciences University of Brighton Brighton BN2 4GJ UK brighton.ac.ukSergey Mikhalovsky - School of Pharmacy and Biomolecular Sciences University of Brighton Brighton BN2 4GJ UK brighton.ac.ukSusan Sandeman - School of Pharmacy and Biomolecular Sciences University of Brighton Brighton BN2 4GJ UK brighton.ac.uk
- Contributors
- Renyun Zhang (Editor)
- Publication Details
- Journal of nanomaterials, v 2018, pp 1-8
- Publisher
- Hindawi
- Grant note
- Department for Business, Innovation and Skills British Council
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000426756700001
- Scopus ID
- 2-s2.0-85043484052
- Other Identifier
- 991014970044404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology