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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection
Nature medicine, v 24(7), pp 923-926
01 Jul 2018
PMID: 29892063
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Antiretroviral therapy during the earliest stage of acute HIV infection (Fiebig I) might minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after analytical treatment interruption. We show that 8 participants, who initiated treatment during Fiebig I and were treated for a median of 2.8 years, all experienced rapid viral load rebound following analytical treatment interruption, indicating that additional strategies are required to control or eradicate HIV.
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Details
- Title
- Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection
- Creators
- Donn J. Colby - Thai Red Cross SocietyLydie Trautmann - Henry M. Jackson FoundationSuteeraporn Pinyakorn - Henry M. Jackson FoundationLouise Leyre - Centre Hospitalier de l’Université de MontréalAmelie Pagliuzza - Centre Hospitalier de l’Université de MontréalEugene Kroon - Thai Red Cross SocietyMorgane Rolland - Henry M. Jackson FoundationHiroshi Takata - Henry M. Jackson FoundationSupranee Buranapraditkun - United States Military HIV Research ProgramJintana Intasan - Thai Red Cross SocietyNitiya Chomchey - Thai Red Cross SocietyRoshell Muir - Drexel UniversityElias K. Haddad - Drexel UniversitySodsai Tovanabutra - Henry M. Jackson FoundationSasiwimol Ubolyam - HIV Netherlands Australia Thailand Research CollaborationDiane L. Bolton - Henry M. Jackson FoundationBrandie A. Fullmer - LeidosRobert J. Gorelick - LeidosLawrence Fox - National Institute of Allergy and Infectious DiseasesTrevor A. Crowell - Henry M. Jackson FoundationRapee Trichavaroj - Armed Forces Research Institute of Medical ScienceRobert O'Connell - Armed Forces Research Institute of Medical ScienceNicolas Chomont - Centre Hospitalier de l’Université de MontréalJerome H. Kim - International Vaccine InstituteNelson L. Michael - United States Military HIV Research ProgramMerlin L. Robb - Henry M. Jackson FoundationNittaya Phanuphak - Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, ThailandJintanat Ananworanich - Thai Red Cross SocietyRv411 Study Grp
- Publication Details
- Nature medicine, v 24(7), pp 923-926
- Publisher
- Springer Nature
- Number of pages
- 6
- Grant note
- W81XWH-07-2-0067 / Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. HHSN261200800001E / National Cancer Institute, National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R01AI108433 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Thai Red Cross AIDS Research Centre W81XWH-07-2-0067 / Division of AIDS at the U.S. National Institute of Allergy and Infectious Diseases R01AI108433 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) W81XWH-07-2-0067 / U.S. Department of Defense (DoD); United States Department of Defense
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Infectious Diseases (and HIV Medicine)
- Web of Science ID
- WOS:000438187700018
- Scopus ID
- 2-s2.0-85048313622
- Other Identifier
- 991019167949704721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Medicine, Research & Experimental