Journal article
Rapid antibiotic efficacy screening with aluminum oxide nanoporous membrane filter-chip and optical detection system
Biosensors & bioelectronics, v 26(1), pp 289-294
15 Sep 2010
PMID: 20650629
Abstract
We have developed a filter-chip and optical detection system for rapid antibiotic efficacy screening. The filter-chip consisted of a 1-mL reservoir and an anodic aluminum oxide (AAO) nanoporous membrane. Sample solution with liquid growth media, bacteria, and antibiotics was incubated in the reservoir for a specific period of time. The number of live bacteria on the surface of membrane was counted after the incubation with antibiotics and filtration. Using this biosensing system, we have demonstrated a 1-h antibiotic screening for patients’ clinical samples, significantly faster than the conventional antibiotic susceptibility tests that typically take more than 24
h. This rapid screening nature makes the filter-chip and detection system ideal for tailoring antibiotic treatment to individual patients by reducing the microbial antibiotic resistance, and improving the survival rate for patients suffering from postoperative infections.
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Details
- Title
- Rapid antibiotic efficacy screening with aluminum oxide nanoporous membrane filter-chip and optical detection system
- Creators
- Pei-Hsiang Tsou - Texas A&M UniversityHarini Sreenivasappa - Texas A&M UniversitySungmin Hong - Texas A&M UniversityMasayuki Yasuike - Fukuda DenshiHiroshi Miyamoto - Saga UniversityKeiyo Nakano - Fukuda DenshiTakeyuki Misawa - Jikei University School of MedicineJun Kameoka - Texas A&M University
- Publication Details
- Biosensors & bioelectronics, v 26(1), pp 289-294
- Publisher
- Elsevier
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Cell Imaging Center
- Web of Science ID
- WOS:000282560500047
- Scopus ID
- 2-s2.0-84755160890
- Other Identifier
- 991022008194304721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biophysics
- Biotechnology & Applied Microbiology
- Chemistry, Analytical
- Electrochemistry
- Nanoscience & Nanotechnology