Journal article
Rapid estimation of octanol–water partition coefficients using synthesized vesicles in electrokinetic chromatography
Journal of Chromatography A, v 962(1), pp 207-219
2002
PMID: 12198964
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Vesicle electrokinetic chromatography (VEKC) using vesicles synthesized from the oppositely charged surfactants cetyltrimethylammonium bromide (CTAB) and sodium octyl sulfate (SOS) and from the double-chained anionic surfactant bis(2-ethylhexyl)sodium sulfosuccinate (AOT) was applied to the indirect measurement of octanol–water partition coefficients (log
P
o/w). A variety of small organic molecules with varying functional groups, pesticides, and organic acids were evaluated by correlating log
P
o/w and the logarithm of the retention factor (log
k′) and comparing the calibrations. A linear solvation energy relationship (LSER) analysis was conducted to describe the retention behavior of the vesicle systems and compared to that of octanol–water partitioning. The solute hydrogen bond donating behavior is slightly different with the vesicle interactions using CTAB–SOS vesicles as compared to the octanol–water partitioning model. The AOT vesicle and octanol–water partitioning systems showed similar partitioning characteristics. VEKC provides rapid separations for determinations of log
P
o/w in the range of 0.5 to 5 using CTAB–SOS vesicles and 0 to 5.5 using AOT vesicles.
Metrics
Details
- Title
- Rapid estimation of octanol–water partition coefficients using synthesized vesicles in electrokinetic chromatography
- Creators
- W.L Klotz - Department of Chemistry, Villanova University, Villanova, PA 19085, USAM.R Schure - Analytical and Computational Technology Center, Rohm and Haas Company, Spring House, PA 19477-0904, USAJ.P Foley - Department of Chemistry, Drexel University, Philadelphia, PA 19104, USA
- Publication Details
- Journal of Chromatography A, v 962(1), pp 207-219
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Web of Science ID
- WOS:000177061400019
- Scopus ID
- 2-s2.0-0037067387
- Other Identifier
- 991014878112004721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Biochemical Research Methods
- Chemistry, Analytical