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Rapidly Progressive Granulomatous Amoebic Encephalitis in a Diabetic Individual
Journal article   Open access   Peer reviewed

Rapidly Progressive Granulomatous Amoebic Encephalitis in a Diabetic Individual

Anish C. Paudel, Nitin Patel, Jonathan Quang, Courtney Casella, Adam Sigal, Prem Parajuli, Olubunmi Oladunjoye, Ibiyemi O. Oke, Suravi Khanal and Kristina Bhattarai
Curēus (Palo Alto, CA), v 13(11), 19336
07 Nov 2021
DOI: https://doi.org/10.7759/cureus.19336
PMID: 34909298
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.7759/cureus.19336View
Published, Version of Record (VoR)CC BY V4.0,  Open

Abstract

General & Internal Medicine Life Sciences & Biomedicine Medicine, General & Internal Science & Technology
We present a case of rapidly progressive granulomatous amoebic encephalitis caused by Balamuthia mandrillaris in an individual with diabetes mellitus. Our patient presented with occipital headache, blurry vision, confusion, and gait imbalance of one week's duration. Brain imaging revealed numerous peripheral ring-enhancing lesions concerning malignancy. Brain biopsy was consistent with Balamuthia mandrillaris infection. He passed away 45 days after presentation despite being treated with a five-drug regimen. This case highlights the importance of considering amoebic brain infections, especially with ring-enhancing lesions on imaging. There are opportunities to design modalities for rapid diagnosis and better treatment.

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Collaboration types
International collaboration
Web of Science research areas
Microbiology
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