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Journal article
Rare case of pancrelipase therapy-induced neutropaenia
BMJ case reports, v 14(3), pe241799
22 Mar 2021
PMID: 33753395
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A 61-year-old man was transferred to our facility from an outside hospital due to refractory neutropaenia of unknown aetiology. The patient presented to the referring hospital with a 5-day history of worsening diarrhoea and abdominal pain. Initial lab results at presentation showed severe neutropaenia with an absolute neutrophil count of 0. Investigations included a bone marrow biopsy which showed slightly hypocellular marrow with near absence of granulocytic precursors. A CT without contrast showed evidence of chronic pancreatitis and acute colitis. The patient's neutropaenia persisted despite granulocyte colony-stimulating factor therapy. The patient was, thus, transferred to our facility for a higher level of care. At our facility, the patient had rapid correction of neutropaenia after discontinuation of pancrelipase therapy. The patient's abdominal pain and diarrhoea also improved while off pancrelipase. Neutropaenia has completely resolved 6 weeks after discharge without any further therapy.
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Details
- Title
- Rare case of pancrelipase therapy-induced neutropaenia
- Creators
- Richard Amoateng - Allegheny Health NetworkBrent Hardman - Allegheny Health NetworkCatherine Liu - Drexel UniversityScarlett Austin - Allegheny Health Network
- Publication Details
- BMJ case reports, v 14(3), pe241799
- Publisher
- British Medical Journal (BMJ)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Emergency Medicine
- Web of Science ID
- WOS:000652594400325
- Scopus ID
- 2-s2.0-85103433893
- Other Identifier
- 991019168441304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, General & Internal