Journal article
Rare complications of osteolysis and periprosthetic tissue reactions after hybrid and non-hybrid total disc replacement
European spine journal, v 24 Suppl 4(Suppl 4), pp S494-501
May 2015
PMID: 25163549
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Few complications have been reported for lumbar total disc replacement (TDR) and hybrid TDR fixations. This study evaluated retrieved implants and periprosthetic tissue reactions for two cases of osteolysis following disc arthroplasty with ProDisc-L prostheses.
Implants were examined for wear and surface damage, and tissues for inflammation, polyethylene wear debris (polarized light microscopy) and metal debris (energy-dispersive X-ray spectroscopy).
Despite initial good surgical outcomes, osteolytic cysts were noted in both patients at vertebrae adjacent to the implants. For the hybrid TDR case, heterotopic ossification and tissue necrosis due to wear-induced inflammation were observed. In contrast, the non-hybrid implant showed signs of abrasion and impingement, and inflammation was observed in tissue regions with metal and polyethylene wear debris.
In both cases, wear debris and inflammation may have contributed to osteolysis. Surgeons using ProDisc prostheses should be aware of these rare complications.
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Details
- Title
- Rare complications of osteolysis and periprosthetic tissue reactions after hybrid and non-hybrid total disc replacement
- Creators
- Sai Y Veruva - Drexel UniversityTodd H Lanman - University of California, Los AngelesJosa A Hanzlik - Drexel UniversitySteven M Kurtz - Drexel UniversityMarla J Steinbeck - Drexel University
- Publication Details
- European spine journal, v 24 Suppl 4(Suppl 4), pp S494-501
- Publisher
- Springer Nature
- Grant note
- R01 AR56264 / NIAMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000355624000006
- Scopus ID
- 2-s2.0-84929089768
- Other Identifier
- 991019167342504721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Orthopedics